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Melatonin has also activated ERK via the MT1 or MT2 receptor or the MT1/MT2 heterodimer in HEK293 and NS1 cells employing the G/PI3K/PKC/cRaf/MEK/ERK cascade (Chen et al., 2020a)

However, its biological relevance is more important, given its role in brain function and bone health, and in the prevention of cardiometabolic diseases