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In cases of zinc deficiency, even short-term supplementation of in average 6 days can significantly improve immune function by decreasing CREM expression and thereby increasing IL-2 production [309]

Indeed, despite attempts to generate a egtA gliK mutant on multiple occasions, using a variety of strategies, no successful egtA gliK mutant was generated (unpublished observations), which indicates that the simultaneous absence of EgtA and GliK is not possible in A

therefore, the ideal treatment is still unclear [20, 21]

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