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doi:10.1021/jf970670x

Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

AOD 9604 failed to achieve regulatory approval after early trials, and retatrutide remains in Phase 3 development without NICE or MHRA guidance

Based on the evidence provided by Evidence Development and Standards and its partners, the Ontario Health Technology Advisory Committeea standing advisory subcommittee of the Health Quality Ontario Boardmakes recommendations about the uptake, diffusion, distribution, or removal of health interventions to Ontarios Ministry of Health and Long-Term Care, clinicians, health system leaders, and policy-makers