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In several studies, researchers demonstrated that doxycycline inhibited matrix MMP activity, which significantly reduced GL shedding and, therefore, leukocyte adhesion to EnCs in response to inflammatory and ischemic stimuli [5, 25, 183]

Targeted modulation of specific VTA connections, while avoiding projections to regions such as the lateral hypothalamus (implicated in autonomic cardiac side effects), may facilitate the development of personalized DBS strategies (Figure D)

While an early study reported an overall reduction in gray matter volume [49] , more recent studies found no significant differences [47,48] , and another study observed increased gray matter in the insular cortex and parts of the limbic system [45]

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