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Consequently, changes in diet quantity and quality may contribute as much as, or more than, direct hormonal effects to observed phase-related glycemic variation

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The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis