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3.4.3 Energy status and oxidative stress balance In OA lesions, synovial inflammation and cartilage degeneration reduce local nutrient availability and oxygen levels, compelling cells to adapt their energy-generating modes (104)

Newer medications are exploring combinations of hormone-based injectables, like glucagon-like peptide-1 agonists, with other agents to improve results and reduce side effects

, 63 , 186-193, doi: Xie, X., Zhao, Y., Ma, C