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A group used PLGA--CD to encapsulate methotrexate (MTX), an antifolate that competitively inhibits dihydro folate receptor (DHFR) which is necessary to synthesize purines and pyrimidines thereby stopping DNA/RNA synthesis in cancer cells leading to its death

MiyamotoJOhue-KitanoRMukouyamaHNishidaAWatanabeKIgarashiMet al

By enhancing glutathione levels, one could potentially mitigate oxidative stress, but there is a nuanced balance

i , Nearest-neighbour Tc to a known human metabolite for generated molecules versus molecules with identical molecular formulas sampled randomly from PubChem, shown separately for each superclass in the ClassyFire chemical ontology