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The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14
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At clinical examination they are observed some hyperpigmented slate-gray macules located bilaterally on the labia majora without defined borders (Figure
The data were analyzed with MassHunter Workstation Software Version B.07.00 (Agilent Technologies, Inc., Santa Clara, CA, United States)
