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Recently, it has been demonstrated that the mechanism of acquired bortezomib resistance is due to the high levels of the GSTP enzyme produced under oxidized conditions [128]
Interestingly, a retrospective cohort study highlighted that cigarette smoking appears to be negatively associated with DIH, which is surprising as induction of CYP2E1 in smokers is expected to increase exposure to toxic metabolites (Zaverucha-do-Valle et al., 2014)
Under conditions of IL-13 stimulation, intracellular GSH levels (and hence GSH:GSSG) fall through 15LO1- and PEBP1-dependent reactions
Larsen, 2003)
