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Sin embargo, la sntesis de novo de colina en los humanos no son suficientes para satisfacer sus necesidades metablicas, de modo que los humanos sanos alimentados con dietas deficientes en colina desarrollan hgado graso, dao heptico, y/o dao muscular (ver Deficiencia)

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These mutants were biochemically analyzed, revealing an altered topology of the Ca 2+ -binding site, thus proposing the role of this region of CRP in its binding to A, with the authors ultimately concluding that CRP is a dual pattern recognition molecule and an antiamyloidogenic protein as well [126]