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Similar content being viewed by others Background According to the World Health Organization, more than 300 million people or 4.4% of the worlds population suffer from depression, representing a substantial global health problem

Sixth, further detailed characterization of the mechanisms that modify the effect of KD-induced neuroprotection is needed, including the role of expression levels of relevant transcription factors, BHB receptors and MCT transporters, local ketone body concentration, gut microbiome species and mitochondrial density and function, all of which could contribute to variation in the response to KD

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