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This capacity comes in part from the fact that their small size allows them to pass through the skin as well as through the blood-brain barrier
Additionally, the highly reactive and electrophilic AFBO attacks DNA at the N7 position on guanine, leading to the DNA lesion [19]

Moreover, the activation of HSCs is closely related to oxidative stress and lipid peroxides caused by long-term alcohol intake (Friedman, 2008

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