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Bone marrow biopsy showed a hypercellular bone marrow with flow cytometry showing an abnormal plasma cell population (1520% plasma cells by immunohistochemistry), consistent with POEMS syndrome

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How TB-500 Works: The Systemic Mechanism Behind the Protocol TB-500s therapeutic effects operate through three primary pathways that inform how the protocol is structured: Actin regulation: Thymosin Beta-4 binds to G-actin (monomeric actin) and regulates its availability for polymerization