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demonstrated that TMAO activates NF-B in aortic endothelial cells via mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinases (ERK) signaling, promoting leukocyte adhesion and vascular inflammation (82)

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A recent study has demonstrated that lactate-induced acidification of the microenvironment over a period of weeks induces a metabolic adaptation of the tumor cell population, promoting -oxidation as a metabolic strategy (the CorbetFeron Effect) 71