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doi: 10.1101/2022.01.12.22269196 138 ZhangN.LiuC.ZhangR.JinL.YinX.ZhengX.et al

We identified notable metabolites that increased or decreased with age (Fig 1A)

lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy

Pre-conception planning should be discussed with a clinician before stopping contraception Mental health considerations : Some patients using GLP-1-based therapies have reported changes in mood