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Wilms, H

6 Redox-endocrine triad: mechanistic intersections of vitamin D, MI, and melatonin 6.1 Shared molecular targets: OS reduction, mitochondrial stabilization, and anti-inflammatory signaling The integral pathophysiology of PCOS is linked to chronic OS, mitochondrial dysfunction, and subclinical inflammation, all of which fuel endocrine and metabolic disturbances (58)

The enzyme activities of COXs were determined spectrophotometrically by monitoring the oxidation of N,N,N,N -tetramethyl- p -phenylenediamine (TMPD) at 610 nm during the conversion of PGG 2 to PGH 2

Additionally, pro-inflammatory factors such as CRP, IL-6 and IL-18, which are closely associated with the incidence of CVDs, are also elevated in the plasma of women with PCOS patients ( The critical role of macrophages in the pathogenesis of CVDs in PCOS has been recently reported, with a substantial augmentation in the number of M1-macrophages in the hearts of PCOS model mice, predominantly derived from circulating monocytes ( 2.3.2 Liver The prevalence of NAFLD is higher in PCOS patients than in healthy women (34%70% vs