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Description
KOR is the same as MOR, which is heavily involved in the integration of reinforcement and aversion stimuli including severe and acute pain, and is mainly distributed in the brainstem, midbrain, and forebrain [28,29,30]
The underlying mechanism/key pathway is illustrated in Figure 2
doi: 10.1098/rstb.2013.0163, 178 ShoreA
Optionally, a controlled-release formulation includes otoprotective agents, such as antioxidants, alpha lipoic acid, calcium, fosfomycin or iron chelators, to counteract potential ototoxic effects that may arise from the use of specific therapeutic agents or excipients, diluents, or carriers
