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KEAP1/NRF2 mutant cells are protected against cysteine-starvation induced ferroptosis due to elevated GCLC expression and limited glutamate accumulation, and dual targeting of cystine import and GCLC activity can overcome the resistance of NRF2 active cells to ferroptosis (Kang et al., Cell Metab 2021)
[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Rowe S., Carr A.C
Table of Contents: What are vitamin B12 injections, and how do they work
A number of substrate concentrations are fixed in the model and in all the simulations reported below
