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We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29

Treatment Overview & Aftercare Treatment duration: 30 minutes About Vitamin B12 Injections Vitamin B12 injections are a safe and effective way to replenish your B12 levels During the procedure Area cleansing at injection site Injection given into chosen area Before your appointment Avoid alcohol 24 hours before Increase water intake before treatment for optimum results Inform of any changes in medications or conditions Procedure details An injection is usually given into your upper arm, but your practitioner may choose a different site depending on your needs Duration of effect Our suggestion is to have one Vitamin B12 injection at weekly intervals, up to four doses (so four doses over four weeks)

B12 is naturally made by bacteria in soil and water but can be grown in industrial-sized vats for use as supplements