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[DOI] [PMC free article] [PubMed] [Google Scholar] 93

This differential tissue regulation of these enzymes results in increased BCAAs in adipose tissue, a decrease in liver BCAAs and no change in skeletal muscle

However, miR-26 also suppresses cholesterol efflux to promote foam cell formation by binding and suppressing ABCA1 and ARL4C in vitro, as observed in RAW264.7 cells, THP-1 cells, and HepG2 cells [23, 59,60,61], suggesting that the formation of foam cells induced by miR-26 may weaken its ability to reduce atherosclerosis

Migrated/invaded cells were counted in a double-blind manner in 5 consecutive fields, using a Zeiss Microscope associated with a Nikon camera