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Specifically, the T alleles of rs8078340 and rs2779249, along with G alleles of rs2779248, lead to higher NO production

If ETC function is impaired, the TCA cycle can continue to generate metabolites by reductive mechanisms, including using pyruvate carboxylase to generate oxaloacetate from pyruvate for aspartate production, and glutamine-dependent reductive carboxylation for citrate synthesis (22, 23)

Wiley Online Library 362(16):33323346
