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The ability of NRF2 to regulate xCT coupled with the decline of NRF2 with age 178 might account for the increased levels of plasma cystine seen with increasing age

Your body produces it on its own, and it circulates in blood plasma, saliva, and urine

10.22074/ijfs.2017.4881 11
Additionally, genes encoding proteins responsible for glutathione synthesis, including SLC7A11, GCLC/GLCM, and GSS are NRF2 target genes (Kerins and Ooi, 2017)
