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doi: 10.3389/fnut.2025.1650328 Received 19 June 2025 Accepted 20 August 2025 Published 03 September 2025 Volume 12 - 2025 Edited by Karolina Wojtunik-Kulesza, Medical University of Lublin, Poland Reviewed by Sara Luz Morales-Lzaro, National Autonomous University of Mexico, Mexico Rogrio Saad Vaz, Federal University of Paran, Brazil Anna Oniszczuk, Doctoral School of Medical University of Lublin, Poland Updates Copyright 2025 Ye, Sun, He, Ai, Jin and Abd El-Aty

11306_2026_2455_MOESM1_ESM.docx (download DOCX Supplementary Material 1 (Linear regression plots of the measured metabolites are given in the supplementary information.) 11306_2026_2455_MOESM2_ESM.xlsx (download XLSX Supplementary Material 2 (Linear regression plots of the measured metabolites are given in the supplementary information.) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-B ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells

Reductive stress also interferes with protein folding in the endoplasmic reticulum, which needs an oxidizing environment to form disulfide bonds properly
