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However, it seems that they are not of interest as medicinal agents

388 Pancreatic cancer (PC) Despite tremendous research efforts in the past few years, PC remains one of the most devastating diseases and has the highest fatality rate among all cancers

For example, the sensitization of TRPA1 with a low dose exposure to acrolein causes sensitization of TRPV1 against capsaicin.[ref] Studies in workplaces that have high VOC levels show that TRPA1 activation is the molecular initial event (MIE) leading to sensory irritation.[ref] A 2022 study investigated the sensitivity to capsaicin, a TRPV1 receptor activator, in people with MCS compared to a control group

Introduction Several metals are toxic to humans exposed through occupational sources, environmental contamination, water and food