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After a chemical peel, the newly exposed skin is highly photosensitive, and unprotected sun exposure within the first week is one of the most reliable ways to trigger hyperpigmentation and undo the results of treatment

Established therapies such as platelet-rich plasma (PRP) have more extensive clinical evidence and regulatory approval for certain applications

Zero completed Phase III trials

Common side effects Injection-site reactions: mild redness, tenderness, swelling, occasional bruising - usually resolve within hours Skin flushing / warmth - brief, related to vasodilation Transient fatigue in the first 12 weeks of intensive protocols Mild headache - usually dose-related Higher-dose theoretical concerns Copper accumulation - each 2 mg injection adds roughly 0.03 mg of elemental copper, trivial next to the 0.92.2 mg from a normal diet