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Trimetazidines main activity in boosting mitochondrial energy generation only when mitochondrial function is reduced, while also targeting inflammation and oxidative stress that occurs in both depression and mania in bipolar disorder makes it a promising novel pharmacotherapy candidate to be tested in clinical trials

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Its essence lies in a complex pathological network that is driven by the overexpression of ER and PR-B

Most research showing benefits for liver markers has used doses in the 500-1000mg range taken as a single daily dose or divided into two doses