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To see whether the increment of Glu in the synaptic cleft caused by GLT-1 cKO affects the expression of ionotropic glutamate receptors, the expression of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) [20] receptor subunit GluA1 and GluA2, and N -methyl-D-aspartate (NMDA) receptor subunit GluN2A and GluN2B were examined (Fig

Isobaric tag-based approaches (iodoTMT and CysTMTRAQ) have been used in several Oxy-Cys PTM studies, redox and electrophile reactive Cys proteome applications ( Perspectives Recent advances in MS-based proteomics, biomarker discovery in the context of neurodegenerative disease has significant potential

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Moreover, the RAPID-OLE study demonstrated that the lung density lost during the two years of placebo treatment is not recovered with the introduction of A1PI, thus highlighting the importance of early therapeutic intervention with a highly purified A1PI product ( Despite recent studies favoring radiological monitoring, several studies have evaluated the effect of therapy on lung function