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Adverse Effects Cough dry, persistent (due to bradykinin) Hyperkalemia decreased aldosterone potassium retention Hypotension especially in volume-depleted patients Angioedema rare but life-threatening Teratogenicity contraindicated in pregnancy Renal impairment in bilateral renal artery stenosis 6

Health Canada has stated that unauthorized injectable peptides cannot lawfully be compounded for human use, and the FDA's December 2024 PCAC review recommended against permitting AOD-9604 in 503A compounding in the United States

*NMIs are subject to change

While many get enough from a balanced diet, certain groups of people may need supplementation, including those following plant-based diets, individuals over 50 or people with specific medical conditions