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Combinational treatment of AUR and proteasome inhibitor (PI) synergistically led to catastrophic cell death, reversible by NAC or protein synthesis inhibitor CHX, yet refractory to blockade of apoptosis, necroptosis or ferroptosis

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Lean mass protection or visceral fat support has become the visible next bottleneck after a stable foundation

Results of the subgroup analyses revealed l-carnitine supplementation decreased DBP levels in participants with overweight and obesity (1.232mmHg, 95% CI: 2.297, 0.167, p=0.023) and with doses of <2g/d (1.639mmHg, 95% CI: 3.038, 0.240, p=0.022)
