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This dependence is substantiated by experimental evidence demonstrating that the ablation of core autophagy genes, such as ATG5 or ATG7 , is sufficient to drive progressive neurodegeneration in animal models, thereby underscoring the indispensability of this pathway for survival [55,56,124]

doi: 10.5604/17322693.1227896 28

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Besides identifying innovative immune targets and establishing concomitant targeting therapeutics against multiple molecules, combining immunotherapy with pro-oxidative approaches may represent another solution to enhance the sensitivity of metastatic cells to immunotherapy