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However, increased HO-1 expression is not necessarily linked to increased heme catabolism and hemolysis, but could rather be a possible consequence of the inflammatory response as, paralleling the upregulation of blood HO-1, was also reported a significant increment of serum ferritin levels (249), an acute phase reactant that can induce anti-inflammatory response by reducing the damage caused by free radicals (250, 251)

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Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils