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Parietal cells in the stomach produce a glycoprotein called intrinsic factor, which is necessary to absorb vitamin B12 in the terminal ileum

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Over recent years two trials with nerve growth factor (NGF) designed to protect forebrain cholinergic neurons (early to moderate stage AD patients) were terminated after phase I [15,16] (NCT00017940, NCT00876863)

Future studies should focus on leveraging single-cell multi-omics technologies to comprehensively characterize the dynamic changes of macrophages within the pulmonary vascular microenvironment, developing cell-specific delivery platforms for precise intervention, and exploring individualized therapeutic strategies based on macrophage phenotyping