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This metabolic stress leads to defective insulin secretion, apoptosis, and dedifferentiation of -cells owing to molecular causes involving a combination of mitochondrial dysfunction, autophagy impairment, inflammation, ER, and oxidative stress (Lytrivi et al., 2020)
The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice
ShanahanFGhoshTSOToolePW
Additionally, the crossover design improves statistical efficiency, as the variance between participants is reduced, allowing for a smaller sample size while maintaining the ability to detect significant effects
