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This disease is characterized by lesions in the affected arteries starting from the intima, followed by a combination of lesions, including lipid accumulation, fibrous tissue proliferation and calcification, along with degenerative changes in the middle layers of the arteries (4)

Inhibition or knockdown of Nrf2 abolished the antioxidant and anti-inflammatory effects of EC, highlighting the pivotal role of Nrf2 activation (Tian et al., 2021)

doi: 10.1007/BF00283624
