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Viral and bacterial infections can potentially decrease vitamin C levels because they generate reactive oxygen and nitrogen species through leukocyte activation that lead to oxidation of extracellular vitamin C [47]

*Correspondence: Yuh-Cherng Chai, [email protected] This article was submitted to Oxidant Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers