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Cell-mediated immunity primarily needs protein antigen degradation in the endocytic vesicles of antigen presenting cells (macrophages, dendritic cells), to be able to present smaller peptides on the cell surface through major histocompatibility complex antigens to activate antigen-specific T cell proliferation

[DOI] [PMC free article] [PubMed] [Google Scholar] Pocernich C.B., Butterfield D.A

Among ROS, H 2 O 2 is the dominant cellular oxidant, and it is a significant contributor to redox regulation (Zorov et al., 2014)

However, formation of the phosphodegron in Nrf2 by GSK-3 is inhibited by stimuli that activate protein kinase B (PKB)/Akt