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Table 1: FDA approved drugs to treat Alzheimers disease and AngIV-based analogs that interact with the HGF/c-Met receptor system

Benefits: Wound healing via increased angiogenesis, anticoagulation, and vasodilation Antioxidant, anti-inflammatory Hair follicle restoration and nail re-growth Skin elasticity restoration and scar tissue repair Healing of intestinal ulcerations in Crohns Increased healing in stress fractures Stomach and intestinal lining repair Protection against Pulmonary Fibrosis, Acute Lung Injury, and Respiratory Distress Syndrome Nerve regeneration, nerve growth factor production supporting cognitive health Protection against neurodegenerative decline via inhibition of beta-amyloid peptide production Down-regulation of over-expressed genes linked to various cancers (ie: metastatic colon) Promotes osteoblasts and marrow stromal cells for increased bone growth Increased improvement of brain fog and energy in elderly patients with anemia (as opposed to replacing with iron) Side Effects: None reported with sublingual delivery

This finding not only supports KPV's candidacy as a research compound for IBD investigation but also unveils a paradigm for drug delivery, exploiting alterations in protein expression to enhance drug localization and activity

Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake