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That said, "well tolerated" is not the same as "risk-free," and responsible buyers should understand both the safety profile and the limits of the evidence

In SOD1 mouse models, endplate denervation was seen prior to clinical weakness and motor neuron loss, suggesting that NMJ compromise occurs early in the pathophysiology of ALS and is often the inciting event prior to lower motor neuron injury (dying back hypothesis) [283]

Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury [published correction appears in Am J Respir Crit Care Med 2001 Sep;164(5):909

FOXO3a and Its Regulators in Prostate Cancer