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These evolutionary studies reveal that fewer clones of cancer cells from the primary tumor site can form metastases in distant organs compared to TDLNs, which might be attributed to the different selective pressures and microenvironments in these organs, such as the varying metabolites in distant organs (161, 162)

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The Vitamin E Isoforms -Tocopherol and -Tocopherol Have Opposite Associations with Spirometric Parameters: The CARDIA Study
