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2 Schematic representation of the interactions between natural antioxidants and the reproductive tract

The introduction of FDA-approved pharmaceutical grade IGF-1 products in the form of Increlex and Iplex is likely to have seen an increase in rhIGF-1 abuse by athletes [97] and in the years that followed a number of newer IGF-1 compounds, analogues and products also became available, some even to the general public [98,99]

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Pyrroloquinoline quinone (PQQ) is a low molecular weight redox compound with strong antioxidant capacity, considered a vitamin cofactor in some bacteria, although not yet classified as essential in humans [40]