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These defects prevent neurons from clearing -syn aggregates, creating a vicious cycle of "autophagy inhibitionprotein aggregation." Lysosomal dysfunction further exacerbates autophagic flux impairment in PD

Semaglutide is an FDA-approved peptide drug used to manage type 2 diabetes and obesity

doi: 10.1136/gutjnl-2015-309957 33 De LorgerilM.SalenP.MartinJ.-L.MonjaudI.DelayeJ.MamelleN
