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Accordingly, the survival advantage acquired by those OAC cells that are in a drug-tolerant persistent (DTP) state reverted to a drug-sensitive phenotype upon interruption of the treatment [17]

The experimental results presented above indicate that mitophagy and mitochondrial biogenesis are closely intertwined, with the interaction between these two processes playing a pivotal role in cellular adaptation and stress resistance (Palikaras and Tavernarakis, 2014)

While important to know about, this warning is based on animal studies and the link has not been found in humans

doi: 10.1111/php.2015.91.issue-1 194 GaffalELandsbergJBaldTSporlederAKohlmeyerJTtingT