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Description

Regulation of enzymatic lipid peroxidation: the interplay of peroxidizing and peroxide reducing enzymes

Introduction Bats are widely known to be reservoir hosts of various zoonotic pathogens, including viral [e.g., Nipah ( Bartonella spp ( Trypanosoma spp ( Flight is highly metabolic demanding and generates harmful free-radical byproducts that damage biologically relevant molecules such as DNA ( Because bat tolerance to pathogens may result from adaptations to cope with flight-induced cellular stress, it has been hypothesized that bats can elicit defenses against intracellular pathogens more effectively than extracellular pathogens (28, 29), distinct mechanisms may potentially exist to cope with these infections