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In contrast to skeletal muscle, the effect of metformin in the liver is mediated by LKB1, as the liver-specific knockout of LKB1 in diabetic mice did not respond to metformin (242)

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For example, the deletion of HDAC9 in mouse CD4 + T cells increases histone H3 lysine 9 acetylation (H3K9ac) and H3K18ac at the PPAR- promoter, promoting a shift in T cell cytokine production toward a more anti-inflammatory profile while reducing the production of anti-dsDNA autoantibodies by B cells