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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
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Understanding where they diverge is the key to understanding why stacking them outperforms either compound alone
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In mammals hepcidins share no significant sequence homologies to any of the known antimicrobial peptides, but they resemble structurally some insect defensins and defensin-like drosomycin (from Drosophila melanogaster ) [155, 156]
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