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Although PTGS2 inhibition currently represents a promising therapeutic approach to combat ferroptosis in osteomyelitis, the fundamental mechanisms of ferroptosisiron dysregulation, lipid peroxidation, and GPX4/SLC7A11 dysfunctionsuggest a broader array of potential therapeutic targets

The effects of age on glutathione peroxidase and glutathione reductase activities in lenses of old world simians and prosimians

This reduced form is critical for glutathione's biological functions, as oxidized glutathione (GSSG) must be recycled back to its reduced form through enzymatic processes before it can provide antioxidant protection

Glutathione, being a natural antioxidant, may present a gentler alternative, but results may take longer to manifest