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The compound produced measurable weight loss, but not enough to meet the regulatory bar for an obesity drug which requires clinically meaningful weight reduction (typically 5%+ of body weight)

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[10] [11] Intramuscular B12 injections (hydroxocobalamin or cyanocobalamin) bypass the digestive system, but UK product information (SmPCs) for hydroxocobalamin injections does list gastrointestinal disturbances, including diarrhoea, as possible adverse reactions, albeit rare