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Wetzels S, Wouters K, Schalkwijk CG, Vanmierlo T, Hendriks JJA
When tested in vitro, most of the synthesized anti-BRD4 PROTACs have shown to significantly degrade the target protein, with the most active compound (124) showing good solubility and a nanomolar degradational potency (DC 50 value of 0.3 nM) 177
doi: 10.1016/j.biortech.2007.12.009
[PubMed: 28911778] 80
