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Yet, individuals with pre-existing conditions may be at increased risk of serious adverse effects (including death) if one considers the possibility that large doses of supplemental vitamin E might interfere with medications, and possibly lower their efficacy or increase their toxicity (1)

Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria

GPX4 Inhibitors Induce Ferroptosis Other ferroptosis inducers directly target glutathione peroxidase 4 (GPX4), a lipid repair enzyme downstream of GSH that works to limit lipid peroxide accumulation ( Figure 3 )

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