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J Ethnopharmacol 36(2):147154 Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019
This study demonstrates that systemic hyperinsulinaemia caused by PI3K inhibitors is sufficient to reactivate the PI3KAKT pathway in tumour models, and that the efficacy of PI3K inhibitors can be improved with anti-glycaemic approaches that prevent hyperinsulinaemia
Yamamoto S, Deguchi K, Onuma M, Numata N, Sakai Y
